Can we use the same building blocks to fabricate biological models that will be able to help cells to work? Can the fabricated models and therapeutic products help us better study biology, target cancers, and develop new drugs?Īs a core technology in biofabrication, bioprinting utilizes cells, proteins and biomaterials as building blocks for 3D-printed biological models, biological systems and therapeutic products. This bioprinting roadmap addresses this unmet need by providing a comprehensive summary and recommendations useful to experienced researchers and newcomers to the field.ġDrexel University, Philadelphia, PA 19104, United States of AmericaĢTsinghua University, Beijing, People's Republic of Chinaįor hundreds of years, cells have been understood to be Nature's building blocks that make us what we are. Due to the rapid pace of methodological advancements in bioprinting techniques and wide-ranging applications, the direction in which the field should advance is not immediately clear. The emerging application of printing-in-space and an overview of bioprinting technologies are also included in this roadmap. The topics covered in this roadmap encompass the broad spectrum of bioprinting from cell expansion and novel bioink development to cell/stem cell printing, from organoid-based tissue organization to bioprinting of human-scale tissue structures, and from building cell/tissue/organ-on-a-chip to biomanufacturing of multicellular engineered living systems. This bioprinting roadmap features salient advances in selected applications of the technique and highlights the status of current developments and challenges, as well as envisioned advances in science and technology, to address the challenges to the young and evolving technique. ![]() Institute of Industrial Science (IIS), The University of Tokyo, Japan Jonsson Comprehensive Cancer Center, University of California Los Angeles, 700 Tiverton, Los Angeles, CA 90024, United States of Americaĭepartment of Radiological Sciences, University of California Los Angeles, 924 Westwood Blvd, Los Angeles, CA 90095, United States of AmericaĬenter for Minimally Invasive Therapeutics (C-MIT), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, United States of America MERLN Institute for Technology-Inspired Regenerative Medicine, Complex Tissue Regeneration department, Maastricht University, Universiteitssingel 40 3rd Floor, room C3.577, 6229 ER Maastricht, The NetherlandsĮngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, United States of Americaĭepartment of Bioengineering, University of California Los Angeles, 410 Westwood Plaza, Los Angeles, CA 90095, United States of AmericaĬalifornia NanoSytems Institute (CNSI), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, United States of America ![]() Institute for Regenerative Medicine, Sechenov Moscow Medical University, 119992, Moscow, Trubetskaya str., 8/2, Russia Mechanobiology Laboratory, Massachusetts Institute of Technology, 500 Technology Square, MIT Building, Room NE47-318, Cambridge, MA, 02139, United States of AmericaģD Bioprinting Solutions, Kashirskoye Shosse, 68, Bld. ![]() School of Engineering and Physical Sciences, Heriot–Watt University, Edinburgh EH14 4AS, United Kingdomĭepartment of Chemical Engineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japanĭepartment of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Namgu, C5 building, room 204, Pohang, Kyungbuk 37673, Republic of Koreaĭepartment of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, Japanĭepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, United States of America Fitts Department of Industrial and Systems Engineering, Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695, United States of Americaĭepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Suite 240 Skirkanich Hall, Philadelphia, PA 19104, United States of Americaĭepartment for Functional Materials in Medicine and Dentistry, University of Würzburg, Universitätsklinikum Würzburg, Pleicherwall 2, 97070 Würzburg, Germanyĭepartment of Biomedical Engineering, University of Strathclyde, Glasgow G4 0NW, United Kingdom Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, United States of Americaĭepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, People's Republic of ChinaĮdward P.
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